基本信息

导师姓名：李绍华

导师职称：讲师

电子邮箱：lsh86@xtu.edu.cn

办公室：化学化工大楼A108

个人简介

         李绍华，男，中共党员，博士，硕士生导师。2025年6月毕业于中山大学，获理学博士学位，2025年7月入职乐天使生物与食品工程系。近年来在Bioresource Technology、Nature Microbiology、Algal Research、Microbial Biotechnology、mSystems、Frontiers in microbiology、Science advances等专业领域重要期刊上发表论文多篇；申请中国发明专利3项，授权2项。

研究方向：

1.藻菌功能活性物质开发及代谢调控

2.天然产物在细菌耐药防控中的应用

3.多组学+机器学习探索食源性致病菌耐药及逆转耐药的机制

主持项目：

1.乐天使fun博士科研启动项目，2025.03-2031.03，在研，主持。

2.湖南省老员工创新训练项目，S202111342018，结题，主持。

主要代表论文：

1.Shaohua Li, Liang Ji, Cheng Chen, Shuxin Zhao, Meng Sun, Zhengquan Gao, Haizhen Wu, Jianhua Fan*. Efficient accumulation of high-value bioactive substances by carbon to nitrogen ratio regulation in marine microalgae Porphyridium purpureum.Bioresource Technology, 2020, 309, 123362.

2.Shaohua Li^#, Liang Ji^#, Qianwen Shi^#, Haizhen Wu, Jianhua Fan*. Advances in the production of bioactive substances from marine unicellular microalgaePorphyridium spp.Bioresource Technology, 2019, 292, 122048.

3.Shaohua Li^#, Jianke Huang^#, Liang Ji, Cheng Chen, Ping Wu, Wei Zhang, Gaoyi Tan, Haizhen Wu, Jianhua Fan a*. Assessment of light distribution model for marine red microalgaPorphyridium purpureumfor sustainable production in photobioreactor.Algal Research.2021,102390.

4.Shaohua Li, Jiao Xiang, Yingyue Zeng, Xuanxian Peng, Hui Li*.Elevated proton motive force is a tetracycline resistance mechanism that leads to the sensitivity to gentamicin in Edwardsiella tarda.Microbial biotechnology,202317(1), e14379.

5.Shaohua Li,Yuan Tao, Zhicheng Yang,Huanzhe Fu, Huiyin Lin,Xuanxian Peng, Hui Li*.Valine potentiates cefoperazone-sulbactam to kill methicillin-resistantStaphylococcus aureus.mSystems, 2025,10(1):e0124424.

6.Shaohua Li^#,Ming Song^#, Peng Wang, Tianshun Kou, Xuan-xian Peng, Hua Ye, Hui Li1*XGBoost- and Mass Spectrometry–Based Feature Selection for Identifying Metabolic Biomarkers Associated with HBV-Related Liver Disease Progression and Hepatocellular Carcinoma Treatment.Journal of Proteome Research,2025.

7.Lichun Mao^#,Shaohua Li^#,Xuanxian Peng, Hui Li*.Global transcriptional regulator FNR regulates the pyruvate cycle and proton motive force to play a role in aminoglycosides resistance ofEdwardsiella tarda.Frontiers in microbiology,2022,13, 1003586.

8.Sufang Kuang^#, Jiao Xiang^#,Shaohua Li^#,Yubin Su^#, Zhuanggui Chen, Hui Li, Bo Peng, Xuanxian Peng*.Metabolic reprogramming enhances the susceptibility of multidrug and carbapenem-resistant bacteria to antibiotics.Nature microbiology,2025,10(9), 2257–2274.

9.Liang Ji,Shaohua Li, Cheng Chen, Haojie Jin, Haizhen Wu and Jianhua Fan*.Physiological and transcriptome analysis elucidates the metabolic mechanism of versatile Porphyridium purpureum under nitrogen deprivation for exopolysaccharides accumulation.Bioresources and bioprocessing,2021,8(1), 73.

10.JianJun Tao,Shaohua Li,Jiahan Wu, Xuanxian Peng, Hui Li*.ptspromoter influences antibiotic resistance via proton motive force and ROS inEscherichia coli.Frontiers in microbiology,2023,14, 1276954.

发明专利：

1.范建华，李绍华，季亮。培养红藻门单细胞海洋微藻生产生物活性成分的方法。授权时间：2022.07.29，授权国别：中国，专利号：CN201910155145.1

2.彭博，李惠，李绍华。亚油酸在制备提高革兰氏阳性菌对抗抗生素敏感性药物中的应用。授权公告时间：2025.07.01，授权国别：中国，专利号：CN202411031248.4

3.彭博,李惠,李绍华.缬氨酸在制备提高细菌对抗生素敏感性药物中的应用, CN119385997A[P]